Endocrine Abstracts

Introduction: A rise in serum insulin levels during GH therapy is reported. Insulin resistance is a risk factor for type 2 diabetes, atherosclerosis, dyslipidemia, and hypertension. Few data describe insulin secretion and lipids after the end of GH therapy.Subjects and methods: Aim of our study was to evaluate changes in insulin secretion, sensitivity and lipid profile in children with isolated GHD longitudinally followed during rhGH treatment. We measur...

Introduction: A rise in serum insulin levels during GH therapy is reported. Insulin resistance is a risk factor for type 2 diabetes, atherosclerosis, dyslipidemia, and hypertension. Few data describe insulin secretion and sensitivity after the end of GH therapy in children.Methods: Aim of our study was to evaluate changes in insulin secretion and sensitivity in 24 children with isolated GHD at 3 times: i) during the last year of therapy (T0); ii) 6 month...

Introduction: Aim of this study was to assess the prevalence of subclinical hypothyroidism in a paediatric population of overweight and obese children and its association with metabolic parameters and with metabolic syndrome (MS).Subjects and methods: Clinical and metabolic evaluations in 600 overweight and obese children and adolescents (310 females, 290 males, 260 prepubertal, 240 pubertal, mean age: 10.7±3.1 years) were performed. MS was defined ...

Introduction: The risk association between the insulin like growth factor-1 (IGF1) and cardiovascular risk is inconclusive in adults and under-explored in the pediatric population. We aimed to investigate the associations between serum concentrations of IGF1 and cardiovascular risk factors in obese children and adolescents.Methods: Cross-sectional study. Clinical and metabolic evaluations including an oral glucose tolerance test (OGTT) were performed at ...